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FINALLY H.I.V VACCINE HAS COME INTO EXISTENCE: THE WORLD HEALTH CELEBRATES



A protein from Simian Immunodeficiency Virus (SIV), which can infect monkeys and apes, has shown promise as a potential component of a vaccine against Human Immunodeficiency Virus (HIV), in a new study from scientists at Scripps Research in La Jolla, California.

Chimpanzee SIV, which can cause an AIDS-like disease in the natural host, is the virus that “jumped” to humans and evolved into HIV roughly a century ago in Africa. SIV’s outer-envelope protein, Env, shares a key structure with HIV’s Env; that and other properties make SIV Env attractive as a potential component of a future vaccine against HIV infection. In the study, published in the May 21 issue of Cell Reports, the Scripps Research scientists found that inoculating mice with SIV Env proteins elicited antibodies that neutralize infection against multiple HIV strains.

“We’ve shown here that one can use shapes from chimpanzee-infecting SIV to stimulate the production of antibodies against the human-infecting HIV,” says co-senior author Dennis Burton, PhD, the James and Jessie Minor Chair in Immunology in the Department of Immunology and Microbiology at Scripps Research. “It’s a simple but inspired strategy, reminiscent of the use of cowpox virus to immunize against smallpox virus over 200 years ago, and should help us in making an HIV vaccine.”

Despite medications that can control HIV and reduce transmission,...




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